Schizencephaly

Schizencephaly is a development disorder characterized by abnormal rives in the cerebral hemispheres (NINDS publication). Some scientists deem it to be a near severe, yet restricted, of the cortical malformations (Volpe, 1995). The pathology of this disorder shows that the chap may be narrow or closed or wide and open. The cleft is unremarkably located near the precentral or postcentral gyri, they can be unilateral (occurring on only one side) or bilaterally symmetric (occurring on some(prenominal) sides). Multiple small convolutions in the worm brain, or polymicrogyria, have been noted. Other malformations included or usually noted with this disorder are microcephaly (small brain), gray consequence heterotopia (absence of binocular equilibrium in the eyes), dysplasia (abnormal tissue development) and hypoplasia (tissue underdevelopment) (Carson, 1996). It has been deemed a cephalic disorder (by NINDS), congenital neurologic malformation (Icenogle & Kap lan, 1981), or a neuronal migration disorder (Volpe, 1995). All are accurate and basically describe some specific characteristics of the disorder. As in both discussion of a neurologic disorder, the discussion of its onset is paired in defining it.

There is believed to be a beat out agenesis of a portion of the germinative zones and thereby the cerebral seawall that leaves the seams or clefts in this anatomical abnormality. This injury in the germinative zones is anyway deemed to affect the migrating neurons-therefore the notion of neuronal migration disorder. Migrational events in the cerebrum accumulate in the third month of gestation. For a better understandi ng, a brief discussion of ontogenesis-the s! ummons of predetermined events occurring in comme il faut sequence to insure normal development of the CNS-is in order. territory ontogenesis of neural tissue is a complex adjoin that can be divided into three developmental phases: (1) embryogenesis from 0 to 1 month of gestation characterized by induction; (2) cellular...If you wishing to get a full essay, order it on our website: OrderEssay.net

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